Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps
Considering the superiority of osteogenesis and vascularization in vivo and in vitro, as well as the modulating of the local inflammatory microenvironment, DPSC-CM synergistic combination deep cryopreservation emerges as a novel strategy of preserving cranial flaps after DC. This multidisciplinary approach establishes a transformative framework for advancing autologous cranial flaps storage technologies, demonstrating translational promise through biological optimization of traditional cryopreservation protocols.
Authors
- Zhifei Ye (ORCID: https://orcid.org/0009-0001-7469-1292)
- Yonghao Liu (ORCID: https://orcid.org/0000-0002-6816-4533)
- C. F. Xu (ORCID: https://orcid.org/0000-0001-8831-3607)
- Wei Xiong (ORCID: https://orcid.org/0000-0003-2754-8888)
- Qingsong Ye (ORCID: https://orcid.org/0000-0002-2868-9247)
- Yan He (ORCID: https://orcid.org/0000-0003-2816-4632)
- Ben Wang (ORCID: https://orcid.org/0000-0002-1191-4591)
- Ye Liu (ORCID: https://orcid.org/0000-0002-6535-5086)
- Junyi Li (ORCID: https://orcid.org/0000-0001-5320-1621)
- Xinxin Wang (ORCID: https://orcid.org/0000-0001-8238-7832)
- Ping Mei (ORCID: https://orcid.org/0000-0003-4121-2133)
- Li Duan
Institutions
- The University of Sydney (AU)
- Nanchang University (CN)
- Wuhan University (CN)
- People’s Hospital of Linqing (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Renmin Hospital of Wuhan University (CN)
- Wuhan University of Science and Technology (CN)
- University of Otago (NZ)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13287-025-04407-1
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- National Natural Science Foundation of China