IL-6R Signaling Is Associated with PAD4 and Neutrophil Extracellular Trap Formation in Patients with STEMI
We demonstrate an association between PAD4, IL-6R, and troponin release in STEMI patients. Our findings indicate a PAD4-mediated connection between IL-6R and NET formation and highlight PAD4 as a potential treatment target for mitigating inflammation and myocardial injury in STEMI.
Authors
- Jostein Nordeng (ORCID: https://orcid.org/0000-0001-9680-9688)
- Svein Solheim (ORCID: https://orcid.org/0000-0003-3321-6572)
- Miriam Sjåstad Langseth (ORCID: https://orcid.org/0000-0002-4880-3019)
- Mathis K. Stokke (ORCID: https://orcid.org/0000-0002-8869-8153)
- Borghild Roald (ORCID: https://orcid.org/0000-0003-2698-2586)
- Hossein Schandiz (ORCID: https://orcid.org/0000-0002-2517-6382)
- Ragnhild Helseth (ORCID: https://orcid.org/0000-0001-5012-9214)
- Ingebjørg Seljeflot (ORCID: https://orcid.org/0000-0003-4071-3358)
- Kristine Mørk Kindberg (ORCID: https://orcid.org/0009-0007-5323-8521)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Institutt for Eksperimentell Medisinsk Forskning (NO)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3390/ijms26115348
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Helse Sør-Øst RHF