Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies
Our results indicate that anti-CD47 treatment induces a stronger cellular and humoral immune response, leading to better protection. As such, immunotherapy by CD47 blockade in combination with vaccines could be a promising approach to improve vaccine efficacy.
Authors
- Hilal Bhat (ORCID: https://orcid.org/0000-0002-1203-1424)
- Eman Farid (ORCID: https://orcid.org/0000-0002-2613-0271)
- Mohamed‐Ridha Barbouche (ORCID: https://orcid.org/0009-0009-4145-8644)
- Lamin B. Cham (ORCID: https://orcid.org/0000-0002-6855-5657)
- Tom Adomati (ORCID: https://orcid.org/0000-0002-1203-1424)
- Thamer A Hamdan (ORCID: https://orcid.org/0000-0003-4977-1191)
- Murtaza Ali
- Khaled Saeed Tabbara (ORCID: https://orcid.org/0000-0003-4278-5320)
- Bello Sirajo (ORCID: https://orcid.org/0000-0001-9225-2704)
Institutions
- Al-Ahliyya Amman University (JO)
- University of Antwerp (BE)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Arabian Gulf University (BH)
- Martin Luther University Halle-Wittenberg (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Vaccines
- Published
- 2025-05-31
- DOI
- https://doi.org/10.3390/vaccines13060602
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Deutsche Forschungsgemeinschaft
- Universität Duisburg-Essen