Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
Although no single metabolite had a causal effect on both a psychiatric and a neurodegenerative disease, results suggest a broad effect of lipids across brain disorders, with a particular role for lipids containing linoleic or arachidonic acid in psychiatric disorders. The metabolites identified here may help inform future targeted interventions.
Authors
- Petroula Proitsi (ORCID: https://orcid.org/0000-0002-2553-6974)
- Pirro G. Hysi (ORCID: https://orcid.org/0000-0001-5752-2510)
- Lachlan Gilchrist (ORCID: https://orcid.org/0009-0005-6484-2105)
- Sulev Kõks (ORCID: https://orcid.org/0000-0001-6087-6643)
- Julian Mutz (ORCID: https://orcid.org/0000-0001-5308-1957)
- Cathryn M. Lewis (ORCID: https://orcid.org/0000-0002-8249-8476)
- Cristina Legido‐Quigley (ORCID: https://orcid.org/0000-0002-4018-214X)
Institutions
- Steno Diabetes Centers (DK)
- Murdoch University (AU)
- King's College London (GB)
- Sørlandet Hospital Arendal (NO)
- Perron Institute for Neurological and Translational Science (AU)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12916-025-04129-4
- Citations
- 6
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 10.90
Funders
- National Institute for Health and Care Research
- Alzheimer’s Research UK
- Perron Institute for Neurological and Translational Science
- NIHR Maudsley Biomedical Research Centre