Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway
Short-term DMOG treatment rejuvenates senescent MSCs by enhancing mitochondrial function, promoting mitophagy via HIF-1α/BNIP3, and improving metabolic reprogramming. DMOG-treated MSCs also showed enhanced therapeutic efficacy in co-culture with IL-1β-treated chondrocytes, suggesting its potential to improve MSC-based therapies in regenerative medicine.
Authors
- Qianqian Cheng (ORCID: https://orcid.org/0000-0002-1567-1996)
- Huanyu Wang (ORCID: https://orcid.org/0000-0003-3981-3394)
- Feng Shuang (ORCID: https://orcid.org/0000-0002-4733-4732)
- Hangyu Ping (ORCID: https://orcid.org/0000-0003-3516-5430)
- Tujun Weng (ORCID: https://orcid.org/0000-0002-5417-7202)
- Yanmin Zhang (ORCID: https://orcid.org/0009-0004-8093-0095)
- Lei Chen (ORCID: https://orcid.org/0000-0001-5094-3902)
- Jingjing Xu (ORCID: https://orcid.org/0000-0003-0390-4120)
- Wei Chai (ORCID: https://orcid.org/0000-0001-8781-9745)
- Lingxian Yi (ORCID: https://orcid.org/0000-0002-4663-4100)
- Jiaxin Wen
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- People's Liberation Army 401 Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13287-025-04422-2
- Citations
- 4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China