Iron-Catalyzed Double Annulation of <i>O</i>-Acyl Oximes with Fumaronitrile for the Synthesis of 4-Cyano-7-azaindoles
An iron-catalyzed double annulation of <i>O</i>-acyl oximes with fumaronitrile has been developed for the concise synthesis of polysubstituted 4-cyano<i>-</i>7-azaindoles. This method enables the construction of two fused heterocycles in a one-step reaction using readily available starting materials under redox-neutral conditions.
Authors
- Cang-Hai Yu
- Hai‐Tao Yang (ORCID: https://orcid.org/0000-0001-9803-5452)
- Chun‐Bao Miao (ORCID: https://orcid.org/0000-0003-4666-2619)
- Xinyu Lyu
- Zhen Cui (ORCID: https://orcid.org/0000-0002-6639-153X)
- Hui Li (ORCID: https://orcid.org/0000-0001-7195-6227)
- Wenya Xu (ORCID: https://orcid.org/0009-0002-9306-2739)
- Wan-Bo Jin
- Xian-Heng Ding
- En-Jun Qiao
Institutions
- Ningbo University of Technology (CN)
- Catalytic Materials (United States) (US)
- Changzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c01769
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Department
- Graduate Research and Innovation Projects of Jiangsu Province