Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice
GX18<i>ca</i> is a promising LAIV candidate. It can induce broad immunity, addressing the cross-protection gaps against evolving EA H1N1 SIVs and zoonotic H1N1 variants, which is crucial for swine influenza control and pandemic preparedness.
Authors
- Huanliang Yang (ORCID: https://orcid.org/0000-0002-2049-332X)
- Zijian Feng
- Yujia Zhai (ORCID: https://orcid.org/0000-0001-5687-0038)
- Hualan Chen (ORCID: https://orcid.org/0000-0001-8910-898X)
- Zuchen Song (ORCID: https://orcid.org/0000-0003-3786-5975)
- Yali Zhang (ORCID: https://orcid.org/0000-0003-1815-0237)
- Yijie Zhang (ORCID: https://orcid.org/0000-0003-2144-333X)
- Yanwen Wang (ORCID: https://orcid.org/0000-0002-7986-4500)
- Chuanling Qiao (ORCID: https://orcid.org/0009-0007-3791-6142)
- Qiu Zhong (ORCID: https://orcid.org/0009-0008-1928-3051)
- Fei Meng (ORCID: https://orcid.org/0009-0005-7016-913X)
- Yan Chen (ORCID: https://orcid.org/0000-0001-7664-7490)
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- Harbin Veterinary Research Institute (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3390/vaccines13060596
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China
- Chinese Academy of Agricultural Sciences
- National Key Research and Development Program of China