Increased [18F]DPA-714 Uptake in the Skeletal Muscle of SOD1G93A Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis
Upregulation of TSPO expression is characteristic of skeletal muscle, but not the brain, in the experimental SOD1<sup>G93A</sup> mouse model of ALS. Tracers targeting this pathway have been mostly proposed for the evaluation of inflammatory processes within the central nervous system. Nevertheless, the ubiquitous nature of TSPO expression and its responsiveness to various signals may broaden the diagnostic potential of these tracers to include disease conditions beyond inflammation.
Authors
- Federica Grillo (ORCID: https://orcid.org/0000-0001-6477-3182)
- Mehrnaz Hamedani (ORCID: https://orcid.org/0000-0002-9371-4832)
- Sabrina Chiesa (ORCID: https://orcid.org/0000-0002-0392-1927)
- Chiara Ghersi
- Cecilia Marini
- Lucilla Nobbio (ORCID: https://orcid.org/0000-0003-2150-3953)
- Marco Milanese (ORCID: https://orcid.org/0000-0003-3384-0666)
- Sonia Carta (ORCID: https://orcid.org/0000-0002-1278-9761)
- Angelo E. Schenone (ORCID: https://orcid.org/0000-0002-2604-7830)
- Carola Torazza (ORCID: https://orcid.org/0000-0003-2236-5142)
- Gianmario Sambuceti (ORCID: https://orcid.org/0000-0003-2979-6500)
- Matteo Bauckneht (ORCID: https://orcid.org/0000-0002-1937-9116)
- Francesco Lanfranchi (ORCID: https://orcid.org/0000-0002-6043-9627)
- Federico Zaottini (ORCID: https://orcid.org/0000-0002-9188-0028)
- Francesca Vitale
- Maddalena Ghelardoni (ORCID: https://orcid.org/0009-0007-8211-1343)
- Mattia Riondato (ORCID: https://orcid.org/0000-0001-9046-7170)
- Alessia Democrito
- Carlo Martinoli (ORCID: https://orcid.org/0000-0001-8201-3849)
- Mattia Camera (ORCID: https://orcid.org/0000-0003-4257-0629)
- Serena Losacco
- Laura Emionite (ORCID: https://orcid.org/0000-0002-5199-6384)
- Edoardo Dighero
- Irene Di Patrizi
Institutions
- Institute of Molecular Bioimaging and Physiology (IT)
- Ospedale Policlinico San Martino (IT)
- National Research Council (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-05-31
- DOI
- https://doi.org/10.3390/biom15060799
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Ministero della Salute