CD73-expressing endometrial regenerative cell-derived exosomes mitigate acute cardiac allograft rejection through regulating adenosine metabolism in mice
CD73 expression is crucial for the ability of ERC-exos to generate adenosine to mitigate acute cardiac allograft rejection in mice. ERC-exos combined with rapamycin can prolong allograft survival.
Authors
- Chenglu Sun (ORCID: https://orcid.org/0000-0001-9927-9344)
- Shaohua Ren (ORCID: https://orcid.org/0000-0002-4400-9045)
- Conglin Wang (ORCID: https://orcid.org/0000-0002-9885-0497)
- Dejun Kong (ORCID: https://orcid.org/0000-0002-6878-9293)
- Hao Wang (ORCID: https://orcid.org/0000-0001-9990-2714)
- Hongda Wang (ORCID: https://orcid.org/0000-0003-2654-261X)
- Shilong Li (ORCID: https://orcid.org/0000-0002-9581-8029)
- Yini Xu
- Hong Qin (ORCID: https://orcid.org/0000-0002-2806-4546)
Institutions
- China Three Gorges University (CN)
- Tianjin University (CN)
- Nankai University (CN)
- Tianjin Medical University General Hospital (CN)
- Inner Mongolia Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13287-025-04398-z
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City