Toward a Deeper Understanding of Clonal Evolution in Acute Myeloid Leukemia: Translational and Clinical Impacts

To understand disease biology of Acute Myeloid Leukemia requires an appreciation of initial clonal heterogeneity of the disease, as well as the selective pressures on these clones and the resulting change in cytomolecular profiles over time. Elucidating these underpinnings of leukemogenesis is critical for attempts to enhance therapeutic efficacy. Here, we review key findings derived from a retrospective analysis of a diverse acute myeloid leukemia cohort of 207 patients and discuss biological mechanisms underlying these trends.