62 (15A) Examining the associations between social determinants of health and lifetime history of parent-reported concussion in children and adolescents in the United States

Magnetic Resonance Spectroscopy (MRS) and hypothesized that concentrations during the subacute recovery period would be associated with physical activity volume.Methods We performed a longitudinal study of participants ages 13-18 years assessed within 21 days of concussion.Participants wore actigraphy devices to monitor physical activity for 14 days after assessment.We created multiple linear regression models using concentrations of four metabolites (Glutathione, Glutamine, Choline, Myo-inositol) as predictor variables, and physical activity volume (steps/day) as the outcome variable.We standardized the four neurometabolites using z-scores.Results We included 16 participants (age=15.61.3 years, 75.0%female, 12.14.4days post-concussion, 70102708 steps/day).After controlling for initial symptom severity, glutathione, glutamate, and total choline, but not myo-inositol, were positively associated with steps/day in the 14-days after assessment (see figure 1).For each z-score increase in Glutathione, participants took 817 additional steps/day (95% CI: -89.2, 1723.4;p=0.07).For each z-score increase of Glutamate, participants took 986 additional steps/day (95% CI : -15.67, 1986.96;p=0.05).For each z-score increase in Total Choline, participants took 1062 additional steps per day (95% CI: -10.34, 2134.95;p=0.05).Conclusion Neurometabolite concentrations in the brain during the subacute recovery phase were associated with physical activity volume over a subsequent 14-day period.While the mechanism for this relationship is not well understood, the ability to use the neurometabolites as a prognostic indicator for behavior (physical activity) after concussion may provide additional insights into physiological barriers related to physical activity participation.