Lutein attenuates rhabdomyolysis-induced acute kidney injury by inhibiting ACSL4-mediated ferroptosis
Tubule-specific knockout of ACSL4 confers protection against RM-induced AKI by inhibiting ferroptosis. Lutein has been shown to prevent ferroptosis in renal tubules by suppressing the expression of ACSL4, suggesting its potential as a pharmaceutical agent to alleviate RM-induced AKI.
Authors
- Chao Liu (ORCID: https://orcid.org/0000-0001-8815-3658)
- Quan Hong (ORCID: https://orcid.org/0000-0002-6839-7695)
- Xian Chang
- Ying Cui (ORCID: https://orcid.org/0000-0002-1764-3526)
- Xiaodong Geng (ORCID: https://orcid.org/0000-0003-1273-4979)
- Zhangning Fu
- Wuhong Zhou
- Feihu Zhou (ORCID: https://orcid.org/0000-0001-6154-013X)
- Yangfan Lv (ORCID: https://orcid.org/0000-0001-9784-2367)
Institutions
- Army Medical University (CN)
- Central Military Commission (CN)
- Chinese PLA General Hospital (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.biopha.2025.118222
- Primary Topic
- Muscle and Compartmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation