Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes
Taken together, these data indicate for the first time that reduced NOX4 expression plays a pivotal role in CB-ECFC angiogenic dysfunction linked with diabetes whilst highlighting NOX4-dependent signalling as a potential target to protect and augment their intrinsic vasoreparative capacity towards addressing current translational barriers.
Authors
- Shun Hay Pun
- Eleanor Gill (ORCID: https://orcid.org/0000-0003-4001-1727)
- Edoardo Pedrini (ORCID: https://orcid.org/0000-0002-2813-9261)
- Yuxin Wu (ORCID: https://orcid.org/0000-0002-2657-8498)
- Reinhold J. Medina (ORCID: https://orcid.org/0000-0003-4351-7010)
- Henning Morawietz (ORCID: https://orcid.org/0000-0001-9360-9736)
- K. O'Neill (ORCID: https://orcid.org/0000-0003-3458-8829)
- Chris Watson (ORCID: https://orcid.org/0000-0001-8749-0732)
- Catherine R. McClintock
- Tinrui Toh
- Arya Moez
- Mohammed Alsaggaf
- Kiran J. McLoughlin (ORCID: https://orcid.org/0000-0003-3815-2600)
- Philip D. Dunne (ORCID: https://orcid.org/0000-0001-9160-283X)
- Rawan A Abudalo
- Jasenka Guduric‐Fuchs
- Bianca Botezatu
- Kevin Edgar (ORCID: https://orcid.org/0000-0002-8057-0104)
- Judith Kandel
- Coy Brunßen (ORCID: https://orcid.org/0000-0002-6421-9752)
- Vinuthna Vani Madishetti
- Xin Ni June Wong
- Karla O’Neill
- David C. Campbell
- Ciarán O’Neill (ORCID: https://orcid.org/0000-0001-7668-3934)
- Jennifer Nicell
- Una McCoy
Institutions
- Queen's University Belfast (GB)
- Hashemite University (JO)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13287-025-04393-4
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Society of the Friendly Sons of St. Patrick for the Relief of Emigrants from Ireland
- Department for the Economy
- British Heart Foundation
- Diabetes UK
- Queen's University Belfast
- Deutsche Forschungsgemeinschaft
- Queen's University
- Medical Research Council