Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis
This study demonstrated that UCHL1 promoted the pro-angiogenic capacity of PDLSCs in periodontitis through the HIF-1α/YAP signaling, which provides insights into the pathogenesis of periodontitis and paves the way for novel treatment strategies.
Authors
- Shucheng Hu (ORCID: https://orcid.org/0009-0005-6585-3017)
- Weijun Yu (ORCID: https://orcid.org/0000-0003-3121-5453)
- Mingzhi Liu (ORCID: https://orcid.org/0000-0001-5842-8307)
- Yuanjie Shi
- Jiaqi Tang (ORCID: https://orcid.org/0000-0002-3544-3456)
- Lin Lu (ORCID: https://orcid.org/0000-0003-0145-8008)
- Eryi Lu (ORCID: https://orcid.org/0000-0002-0045-2571)
- Yuting Gu (ORCID: https://orcid.org/0000-0001-5891-0101)
- Min Jin (ORCID: https://orcid.org/0000-0003-0073-4816)
- Yue Shen (ORCID: https://orcid.org/0000-0002-5987-2415)
- Zhurong Cui
- Ruhan Yang
- Guanglong Li
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13287-025-04399-y
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- Chinese Academy of Medical Sciences
- Renji Hospital