Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines
Our findings suggest that sTREM-1 may be a clinically informative marker of neutrophil activation, associated with hemoconcentration, systemic inflammation, and endothelial activation and in dengue fever.
Authors
- Michelle Ngai
- Ashley Roberts (ORCID: https://orcid.org/0000-0002-6273-542X)
- Maria Salome Siose Painaga
- Kevin C. Kain (ORCID: https://orcid.org/0000-0001-6068-1272)
- Jiayi Yang (ORCID: https://orcid.org/0000-0001-7833-7787)
- Michael Hawkes (ORCID: https://orcid.org/0000-0002-4122-0937)
- Hridesh Mishra (ORCID: https://orcid.org/0000-0002-8572-2736)
- Vanessa Tran (ORCID: https://orcid.org/0000-0001-6955-5483)
- James Yared Gaite
Institutions
- University of the Philippines Cebu (PH)
- University Health Network (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Toronto General Hospital Research Institute
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1371/journal.pntd.0013084
- Citations
- 2
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Rotary Foundation
- BC Children's Hospital
- Canada Research Chairs
- Canadian Institutes of Health Research