Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway
Our results show that APT can attenuate iron overload-induced cartilage damage in vivo and in vitro via the NRF2/HO-1 pathway. We demonstrated for the first time that APT has promising applications in iron overload diseases.
Authors
- Shaocong Li
- Fangning Wan (ORCID: https://orcid.org/0000-0001-5258-1626)
- Zhaofeng Pan (ORCID: https://orcid.org/0000-0003-3478-8855)
- Bai‐Hao Chen
- Jiacong Xiao
- Dongling Cai (ORCID: https://orcid.org/0000-0003-4101-2772)
- Miao Li (ORCID: https://orcid.org/0009-0004-8775-686X)
- Chi Zhou (ORCID: https://orcid.org/0000-0003-1905-9494)
- Qi He
- Haibin Wang (ORCID: https://orcid.org/0000-0002-0112-1408)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Panyu Hospital of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1371/journal.pone.0317930
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China