Mediating role of systemic inflammation in linking transferrin saturation to all-cause mortality in patients with coronary artery disease: Evidence from a large population-based study
TS demonstrates a U-shaped relationship with all-cause mortality in CAD patients. Systemic inflammation is linked to both TS and mortality outcomes, suggesting potential mechanistic interplay. Maintaining TS within 20-30% and addressing inflammation may reduce mortality risk.
Authors
- Zhenzhen Chen (ORCID: https://orcid.org/0000-0002-5394-6583)
- Yingying Guan (ORCID: https://orcid.org/0000-0002-4021-3751)
- Juan Guo (ORCID: https://orcid.org/0000-0002-9302-5818)
- Simin Wang (ORCID: https://orcid.org/0000-0001-6409-7700)
- Haoying Chen (ORCID: https://orcid.org/0000-0003-0498-1232)
- Zhou Jianyu
Institutions
- General Electric (Spain) (ES)
- Taizhou Central Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1371/journal.pone.0322633
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00