Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study
This cohort study of older nursing home residents showed that initiation of CYP2D6-metabolized opioids on existing CYP2D6-inhibiting (versus CYP2D6-neutral) antidepressants was associated with increased risk of worsening pain, pain-related hospitalizations, and pain-related ED visits, although the relative and absolute risks are small to moderate. Clinicians should be aware of potential worsening pain and hospital and ED visits due to pain among patients who used CYP2D6-metabolizing opioids concomitantly with antidepressants, particularly those with CYP2D6-inhibiting antidepressants.
Authors
- Michael J. Daniels (ORCID: https://orcid.org/0000-0002-9856-9486)
- Yu‐Jung Jenny Wei (ORCID: https://orcid.org/0000-0001-8861-6907)
- Siegfried Schmidt (ORCID: https://orcid.org/0000-0001-5941-6009)
- Stephan Schmidt (ORCID: https://orcid.org/0000-0002-4998-1167)
- Almut G. Winterstein (ORCID: https://orcid.org/0000-0002-6518-5961)
- Roger B. Fillingim (ORCID: https://orcid.org/0000-0002-7699-8183)
- Steven T. DeKosky (ORCID: https://orcid.org/0000-0003-3743-2758)
Institutions
- Center for Drug Evaluation and Research (US)
- University of Florida Health (US)
- University of Florida (US)
- The Ohio State University (US)
- University of Florida Health Science Center (US)
- Florida College (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1371/journal.pmed.1004620
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- National Institute on Aging