A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels
Our results indicate that while Orai1α and Orai1β mostly form separate CRAC channels, a small subset of both Orai1 variants combine to form heteromeric channels. These findings provide new insights on the nature of CRAC channels.
Authors
- José J. López (ORCID: https://orcid.org/0000-0002-5234-1478)
- Sandra Alvarado (ORCID: https://orcid.org/0000-0002-3851-5531)
- Tarik Smani (ORCID: https://orcid.org/0000-0002-1877-7438)
- Alvaro Macias‐Díaz (ORCID: https://orcid.org/0009-0002-8638-7957)
- Joel Nieto‐Felipe (ORCID: https://orcid.org/0000-0001-6342-3893)
- Francisco Javier Martı́n-Romero (ORCID: https://orcid.org/0000-0001-6796-7396)
- Isaac Jardín (ORCID: https://orcid.org/0000-0003-4575-8264)
- Juan A. Rosado (ORCID: https://orcid.org/0000-0002-9749-2325)
- Vanesa Jimenez‐Velarde (ORCID: https://orcid.org/0009-0004-8422-4921)
Institutions
- Instituto de Biomedicina de Sevilla (ES)
- Universidad de Sevilla (ES)
- Universidad de Extremadura (ES)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12964-025-02271-3
- Citations
- 2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Ministerio de Ciencia e Innovación
- Junta de Extremadura
- Universidad de Extremadura
- European Regional Development Fund
- Agencia Estatal de Investigación