Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow-up: Relation to Dysglycemia
Type 1 diabetes has detrimental effects in white matter in young children. We performed a longitudinal study using brain MRI (diffusion tensor imaging) and cognitive assessments in 4- to 9-year-old children, control participants without diabetes (n = 71) and with type 1 diabetes (n = 143), plus continuous glucose monitoring, to assess changes at four time points as children grow over 6-8 years. White matter myelination and fiber integrity were assessed using axial diffusivity, which was decreased in the diabetes versus control group, less so during puberty, and fractional anisotropy was reciprocally related to hyperglycemia. Data suggest continued negative impact of chronic hyperglycemia in the developing brain.
Authors
- Matthew Marzelli (ORCID: https://orcid.org/0000-0001-9171-4161)
- William V. Tamborlane (ORCID: https://orcid.org/0000-0002-9928-559X)
- Allison Cato (ORCID: https://orcid.org/0000-0002-9097-3468)
- Eva Tsalikian (ORCID: https://orcid.org/0000-0003-3429-2796)
- Ana María Arbeláez (ORCID: https://orcid.org/0000-0001-6977-9786)
- Tamara Hershey (ORCID: https://orcid.org/0000-0001-7549-0698)
- Tandy Aye (ORCID: https://orcid.org/0000-0002-9005-3303)
- Nelly Mauras (ORCID: https://orcid.org/0000-0003-1175-3852)
- Stuart A. Weinzimer (ORCID: https://orcid.org/0000-0002-7768-5189)
- Allan L. Reiss (ORCID: https://orcid.org/0000-0002-1979-4942)
- Booil Jo (ORCID: https://orcid.org/0000-0001-8855-147X)
- Bruce A. Buckingham (ORCID: https://orcid.org/0000-0003-4581-4887)
- Kim Englert
- Qianheng Ma (ORCID: https://orcid.org/0000-0002-5845-5644)
- Neil H. White (ORCID: https://orcid.org/0000-0002-4701-1976)
- Michael Tansey (ORCID: https://orcid.org/0000-0002-8157-8423)
- Larry A. Fox (ORCID: https://orcid.org/0000-0002-2254-6560)
Institutions
- University of Iowa (US)
- Washington University in St. Louis (US)
- Yale University (US)
- Nemours Children's Health System (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-06-02
- DOI
- https://doi.org/10.2337/db24-0684
- Citations
- 5
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- U.S. Department of Health and Human Services
- Eli Lilly and Company
- AstraZeneca
- Sanofi
- Yale University
- University of Minnesota
- Washington University in St. Louis
- University of Pittsburgh
- Nemours Foundation
- Insulet Corporation
- Dexcom
- Novo Nordisk
- National Institutes of Health
- School of Medicine, Stanford University
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development