The Mouth Tells the Tale: Kaposi Sarcoma as the First Clue to Undiagnosed AIDS

Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus-8 (HHV-8), most commonly seen in individuals with advanced human immunodeficiency virus (HIV)/AIDS. We report the case of a 52-year-old male patient with no known HIV history who presented with a three- to four-month history of worsening sore throat, oral pain, diarrhea, weight loss, and systemic symptoms including night sweats and fatigue. The patient was eventually diagnosed with oral KS based on pathological results. This case highlights KS as a potential initial manifestation of advanced HIV/AIDS and the importance of early recognition and treatment.