Management and Outcomes of Women With Low Fibrinogen Concentration During Pregnancy or Immediately Postpartum: A UK National Population-based Cohort Study

( Acta Obstet Gynecol Scand . 2024;103(7):1339–1347. doi: 10.1111/aogs.14828) Obstetric hemorrhage is a major cause of maternal morbidity and mortality, often linked to early coagulopathy during events like placental abruption. Fibrinogen is vital for clot formation and is typically the first indicator of coagulopathy in postpartum hemorrhage (PPH). Guidelines suggest maintaining maternal plasma fibrinogen levels equal to or above 2 g/L during PPH, as lower levels are associated with ongoing bleeding and increased blood product use. However, slow laboratory coagulation results and unclear evidence on the benefits of fibrinogen replacement complicate management.