Impact of DNA methylation on the recurrence risk of stage I non-small cell lung cancer with EGFR mutations
Our study demonstrates that the methylation of five genes-CDO1, TAC1, p16, CDH13, and APC-in N2 lymph nodes represents a strong biomarker panel for predicting recurrence in stage IB EGFRm NSCLC after curative resection. This approach also shows exceptional predictive accuracy for postoperative recurrence in stage IA2-IA3 EGFRm NSCLC.
Authors
- Fang Wu (ORCID: https://orcid.org/0000-0002-6627-3437)
- James G. Herman (ORCID: https://orcid.org/0000-0001-8102-1740)
- Xue He (ORCID: https://orcid.org/0000-0003-4448-5399)
- Qingchun Liang (ORCID: https://orcid.org/0000-0001-9318-2357)
- Fenglei Yu (ORCID: https://orcid.org/0000-0003-3409-065X)
- Wenliang Liu (ORCID: https://orcid.org/0000-0003-4202-8637)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- Yunyi Li (ORCID: https://orcid.org/0009-0009-8957-6295)
- Zhihui Yang (ORCID: https://orcid.org/0000-0002-9289-013X)
- Malcolm V. Brock
Institutions
- Central South University (CN)
- Johns Hopkins University (US)
- Sidney Kimmel Cancer Center (US)
- UPMC Hillman Cancer Center (US)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13148-025-01899-9
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province
- Xiangya Hospital, Central South University