Association of the triglyceride-glucose index and its modifications with metabolic syndrome in young people

Abstract. Introduction. In recent decades, there has been a significant increase in the number of metabolic syndrome cases, requiring special attention and the use of new methods for its diagnosis, prognosis and treatment monitoring. Aim. To analyze the association of triglyceride-glucose index and its modifications with the presence of metabolic syndrome in young adults. Materials and Methods. The case-control study involved 863 young people aged 18-44 years. Anthropometric and laboratory studies were conducted, including the calculation of insulin resistance indices and assessment of their association with metabolic syndrome. The logistic regression method was used in statistical processing. Results and Discussion. When analyzing the contribution of insulin resistance indices, the triglyceride- glucose index demonstrated the greatest association with the presence of metabolic syndrome: With an increase of 1 unit, the chances of detection increased by 12.06 times, which is 7.25 times more often than the HOMA-IR index and 3.75 times more often than the triglyceride-glucose index – waist circumference to height ratio. Conclusions. The triglyceride-glucose index is an important tool for assessing insulin resistance and its use, taking into account gender and ethnic differences, allows achieving optimal results in the diagnosis and prevention of metabolic syndrome.