Genotype-negative hypertrophic cardiomyopathy: Exploring the role of cardiovascular risk factors in disease expression
CVRF, particularly hypertension, are more prevalent in G- patients independent of age, suggesting that cardiovascular health may contribute to HCM disease development. Male-female differences suggest female-specific factors affecting the development of HCM in women. Recognizing G- HCM as a distinct clinical entity may have important implications for patient management, and a more comprehensive understanding of its aetiology may aid in tailoring future therapies.
Authors
- Edgar E. Nollet (ORCID: https://orcid.org/0000-0001-7047-2538)
- Jolanda van der Velden (ORCID: https://orcid.org/0000-0001-5224-5788)
- Stephan A C Schoonvelde (ORCID: https://orcid.org/0000-0001-6235-016X)
- Judith M.A. Verhagen (ORCID: https://orcid.org/0000-0002-0340-3433)
- Michelle Michels (ORCID: https://orcid.org/0000-0001-6432-0431)
- Arend F. L. Schinkel (ORCID: https://orcid.org/0000-0002-6424-0754)
- Rudolf A. de Boer (ORCID: https://orcid.org/0000-0002-4775-9140)
- Peter-Paul Zwetsloot (ORCID: https://orcid.org/0000-0002-2634-4667)
- Marjon A. van Slegtenhorst
- Alexander Hirsch (ORCID: https://orcid.org/0000-0002-3315-2006)
- Tjeerd Germans (ORCID: https://orcid.org/0000-0003-2781-0145)
- Christian Knackstedt
Institutions
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Maastricht University (NL)
- Northwest Hospital (US)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.ijcard.2025.133444
- Citations
- 8
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.11