PKCα Phosphorylates FACI to Switch Its Function in Clathrin-mediated Endocytosis to a Presumed Role in Macropinocytosis in Intestinal and Hepatic Cells
FACI modulates clathrin-mediated endocytosis and macropinocytosis in intestinal and hepatic cells. Protein kinase Cα phosphorylates FACI to switch its function in endocytosis to a presumed role in macropinocytosis in these cells. FACI facilitates enteric pathogen invasion by enhancing macropinocytosis in the intestine.
Authors
- Yun Cheng (ORCID: https://orcid.org/0009-0007-0479-5671)
- Xiao-Zhuo Kang
- Kam‐Leung Siu (ORCID: https://orcid.org/0000-0001-8472-6834)
- Dong‐Yan Jin (ORCID: https://orcid.org/0000-0002-2778-3530)
- Sin‐Yee Fung (ORCID: https://orcid.org/0000-0002-5184-6781)
Institutions
- University of Hong Kong (HK)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101551
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health and Medical Research Fund