Seeking standardized in vitro models of AGE-RAGE signaling in the physiological perspective of glycated dietary proteins
These results challenge the hypothesis that dietary AGEs cause inflammation via RAGE activation, as glycated dietary proteins alone do not seem to induce acute inflammation. To better understand the biological activity of dietary AGEs, future studies should confirm surface RAGE expression, detail glycation methods and glycated protein characteristics, and account for LPS interference.
Authors
- Tamara Hoppenbrouwers (ORCID: https://orcid.org/0000-0002-1764-9100)
- Josep Rubert (ORCID: https://orcid.org/0000-0002-1634-2334)
- Vincenzo Fogliano (ORCID: https://orcid.org/0000-0001-8786-9355)
- Fleur A. C. Jansen (ORCID: https://orcid.org/0000-0002-8314-2543)
- Klaske van Norren
Institutions
- Wageningen University & Research (NL)
Publication Details
- Journal
- International Journal of Biological Macromolecules
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.ijbiomac.2025.144889
- Citations
- 2
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 2.64