A Straightforward Access to Specific Bisindole Systems Related to Fascaplysin Alkaloids
Abstract This study presents a a straightforward synthetic approach to the specific pentacyclic bisindole structures related to fascaplysin alkaloids. The key transformation is an acid-promoted cascade involving a C–N bond formation/Mannich-type cyclization/dehydrogenation sequence. Nineteen novel bisindole derivatives bearing a wide range of functional groups were prepared by this method.
Authors
- Zizhen Wang (ORCID: https://orcid.org/0000-0002-1401-1873)
- Sijun Liu
- Liang Chen
- Yan Li (ORCID: https://orcid.org/0000-0003-2083-6991)
Institutions
- Guiyang Medical University (CN)
- Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Synlett
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1055/a-2626-0265
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guizhou Province