Lidocaine for Neuropathic Cancer Pain (LiCPain): A Pilot Randomized Controlled Trial
This pilot demonstrates that a phase III clinical trial of extended continuous subcutaneous infusion of lidocaine for neuropathic cancer pain is feasible and provides important insights into modifications required to improve recruitment. Serum levels and relative safety suggest higher lidocaine doses could be cautiously evaluated. As the only prospective trial we are aware of to date, this trial informs clinical use of subcutaneous lidocaine infused over days.
Authors
- Nikki McCaffrey (ORCID: https://orcid.org/0000-0003-3684-3723)
- David C. Currow (ORCID: https://orcid.org/0000-0003-1988-1250)
- Jane Phillips (ORCID: https://orcid.org/0000-0002-3691-8230)
- Marian Kow
- Kat Urban
- Jessica Lee (ORCID: https://orcid.org/0000-0003-1570-066X)
- Dipti Mittal
- Bill Noble (ORCID: https://orcid.org/0000-0002-9525-7970)
- Anthony Linton (ORCID: https://orcid.org/0000-0003-0272-0813)
- Belinda Butcher (ORCID: https://orcid.org/0000-0002-1415-4065)
- Andrew J. McLachlan (ORCID: https://orcid.org/0000-0003-4674-0242)
- Priyanka Vandersman (ORCID: https://orcid.org/0000-0001-8527-6994)
- Belinda Fazekas
- Caitlin Sheehan (ORCID: https://orcid.org/0000-0001-5100-0746)
- Megan Ritchie
- Christine Sanderson (ORCID: https://orcid.org/0000-0001-5423-5778)
- Meera Agar (ORCID: https://orcid.org/0000-0002-6756-6119)
- Richard Chye (ORCID: https://orcid.org/0000-0003-1506-9572)
- Davinia S. E. Seah (ORCID: https://orcid.org/0000-0002-5964-1721)
- Ghauri Aggarwal
- Angela Rao (ORCID: https://orcid.org/0000-0002-7904-5556)
- Rajesh Aggarwal (ORCID: https://orcid.org/0000-0001-9424-9621)
- Chadi Ayoub (ORCID: https://orcid.org/0000-0001-5877-7478)
- Melanie Lovell (ORCID: https://orcid.org/0000-0002-1407-2748)
- Rachel George
- Eugenia Hutton
Institutions
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- University of Tasmania (AU)
- Deakin University (AU)
- Flinders University (AU)
- Concord Repatriation General Hospital (AU)
- Flinders Medical Centre (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- Government of the Northern Territory (AU)
- Northern Sydney Local Health District (AU)
- Mayo Clinic in Arizona (US)
- Calvary Hospital (AU)
- Sydney Local Health District (AU)
Publication Details
- Journal
- Journal of Pain and Symptom Management
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jpainsymman.2025.05.015
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33