Activation of LAMP1-mediated lipophagy by sulforaphane inhibits cellular senescence and intervertebral disc degeneration
This study indicates that the therapeutic effects of sulforaphane in mitigating lipid accumulation and senescence can provide an effective treatment strategy for delaying the progression of IDD in the future.
Authors
- Naibo Feng (ORCID: https://orcid.org/0000-0001-6426-2411)
- Houqing Long (ORCID: https://orcid.org/0000-0003-4480-7298)
- Chungeng Liu
- Guozhi Xiao (ORCID: https://orcid.org/0000-0002-4269-2450)
- Yongheng Xie
- Songlin Peng (ORCID: https://orcid.org/0000-0002-4042-7071)
- Mingxi Zhu (ORCID: https://orcid.org/0000-0001-5513-0038)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-4248-7681)
- Tianyu Qin (ORCID: https://orcid.org/0000-0002-2816-2648)
- Ming Shi (ORCID: https://orcid.org/0000-0002-9905-6316)
- Yining Chen
- Wanli Zheng
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- Central Hospital of Zibo (CN)
- Shenzhen Second People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jot.2025.05.010
- Citations
- 2
- Primary Topic
- Plant Toxicity and Pharmacological Properties
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China