Chain-release of quinoline-based drugs from <i>N</i>-alkoxyquinoline prodrugs upon radiolytic one-electron reduction
Quinoline and isoquinoline prodrugs containing <i>N</i>-alkoxy substituents release the quinoline drug and a reducing radical upon radiolytic one-electron reduction in aqueous solution under anoxia. The radical reduces a further prodrug forming a long chain reaction producing high concentrations of the quinolines.
Authors
- Andrew J. Marshall (ORCID: https://orcid.org/0000-0003-0022-2001)
- Hamish S. Sutherland
- Robert F. Anderson (ORCID: https://orcid.org/0000-0003-4100-3294)
Institutions
- University of Auckland (NZ)
- Victoria University of Wellington (NZ)
- Cancer Society of New Zealand (NZ)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01641j
- Citations
- 1
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.79