PREVALENCE AND ANTIBIOTIC RESISTANT PATTERN OF STAPHYLOCOCCUS AUREUS IN CLINICAL ISOLATES FROM PESHAWAR: A SINGLE CENTER STUDY

The health authorities recognize S. aureus as a severe public health problem because of its varied pathogenicity while antibiotics lose their effectiveness against this pathogen. The main goal of this research was to analyze S. aureus resistance patterns among hospital patients from Peshawar's tertiary care facility in Pakistan. The research work was carried out in the Pathology section of Rehman Medical Institute from July 2022 to December 2022. The study processed 400 samples were obtained. The research team performed morphological as well as biochemical identification of the isolates followed by antibiotic susceptibility testing through Kirby-Bauer disk diffusion testing methods. The positive results for bacteria reached 78.25% from 400 collected samples and S. aureus emerged as one of the 10% types of isolates found. The study showed resistance towards Cefoxitin, Levofloxacin, and Erythromycin 74.35%, 69.23%, and 64.10% respectively. The bactericidal activities of Vancomycin, Linezolid, as well as Rifampicin, demonstrated high efficiency in combating bacterial pathogens. The research demonstrates antibiotic-resistant S. aureus strains have appeared in this region demonstrating the necessity of enhancing antibiotic-use strategies and steady monitoring for S. aureus resistance patterns to stop global S. aureus infection threats.