Challenging the preclinical paradigm: Adverse effects of antiseizure medicines in male rats with drug‐resistant epilepsy
This study highlights the need for preclinical models that better reflect human epilepsy, considering both efficacy and side effects in drug development. Our findings emphasize the complexity of drug responses and underscore the importance of improved models for drug development.
Authors
- Jonathan Vuong
- Michelle Guignet (ORCID: https://orcid.org/0000-0003-4788-0175)
- H. Steve White (ORCID: https://orcid.org/0000-0003-4550-4408)
- Ticha Ballapapinan
- Nicholas Uribe
Institutions
- University of Washington (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/bph.70076
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- American Epilepsy Society
- Epilepsy Society
- National Institutes of Health
- National Center for Advancing Translational Sciences