Study on the Influence of Mid-Infrared Vibrational Strong Coupling and Resonance Absorption on Biological Reaction

中红外波段(Mid-Infrared, MIR)覆盖许多分子振动模式，这一区域与分子振动–转动能级跃迁高度相关，通过这一特性可以实现光对生化反应的调控。振动强耦合(Vibrational strong coupling, VSC)与共振吸收作为研究光与物质相互作用的两种方法逐渐成熟。腺嘌呤核苷三磷酸(Adenosine triphosphate, ATP)是生物体的直接供能物质，其水解释放的能量可驱动多种生命活动。当法布里–珀罗微腔被调控到与水分子的O-H伸缩振动模式(3405 cm−1)耦合时，在VSC的影响下，氢键与疏水作用发生改变，因此ATP的水解效率得到提升。当使用对应频率的中红外光作用ATP溶液时，由于共振吸收增强分子键振幅，ATP的水解效率也得到了提高。这一研究为深入探索和有效利用物理频率手段调控生命反应开辟了崭新的研究路径，有望成为光学在医学和生物学领域的革命性工具。Mid-infrared (MIR) covers many molecular vibration modes, which is highly correlated with the molecular vibration rotation energy level transition. Through this characteristic, the regulation of biochemical reactions by light can be realized. Vibrational strong coupling (VSC) and resonance absorption are gradually maturing as two methods for studying the interaction between light and matter. Adenosine triphosphate (ATP) is a direct energy source for living organisms, and the energy released from its hydrolysis can drive various life activities. When the Fabry-Pérot microcavity is tuned to couple with the O-H stretching vibration mode (3405 cm−1) of water molecules, under the influence of VSC, the hydrogen bond and hydrophobic interaction change, thus improving the hydrolysis efficiency of ATP. When mid-infrared light of the corresponding frequency is applied to an ATP solution, the hydrolysis efficiency of ATP has also been improved due to resonance absorption enhancing molecular bond amplitude. This research has opened up a new research path for in-depth exploration and effective use of physical frequency means to regulate life response, and is expected to become a revolutionary tool of optics in the field of medicine and biology.