Oligomeric monoterpenoid indole alkaloids from the flowers of <i>Gelsemium elegans</i> with anti-inflammatory and anti-fibrotic activities
Six oligomeric monoterpenoid indole alkaloids with new skeletons (1–6) were isolated from the flowers of Gelsemium elegans . Compound 3 alleviated inflammation and liver fibrosis, and was biomimetically synthesized.
Authors
- Min-Jing Cheng (ORCID: https://orcid.org/0009-0008-0072-7433)
- Hai-Feng Lin
- Wen‐Cai Ye (ORCID: https://orcid.org/0000-0002-2810-1001)
- Ni-Ping Li
- Lei Wang (ORCID: https://orcid.org/0000-0001-9242-1109)
- Ji‐Hong Gu (ORCID: https://orcid.org/0000-0001-7680-8143)
- Yiyi Li (ORCID: https://orcid.org/0000-0003-4774-2493)
- Jun-Shan Liu (ORCID: https://orcid.org/0000-0003-3744-6180)
- Ling Dai
- Jian Hong (ORCID: https://orcid.org/0000-0002-2174-4928)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Laboratoire de Chémo-biologie synthétique et thérapeutique (FR)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00551e
- Citations
- 1
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project
- Science and Technology Planning Project of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province