Dinickel-catalyzed regio- and enantioselective α-alkylation of cyclic ketones with unactivated alkyl halides
The asymmetric α-alkylation of cyclic ketones with unactivated alkyl halides was realized with a unique dinickel catalyst with high regio- and enantioselectivities. It proceeds through an S N 2 displacement of alkyl halides by nickel( i ) enolates.
Authors
- Ruopeng Bai (ORCID: https://orcid.org/0000-0002-1097-8526)
- Liangwei Zhu
- Zhong‐Lin Tao (ORCID: https://orcid.org/0009-0008-4953-9177)
- Peigen Wang (ORCID: https://orcid.org/0000-0001-9255-1712)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-7404-5231)
- Jian Zhang (ORCID: https://orcid.org/0000-0003-3373-9621)
Institutions
- Chongqing University (CN)
- Hunan University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00448a
- Citations
- 3
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for the Central Universities