CURRENT USE AND OUTCOMES OF HEMATOPOIETIC CELL TRANSPLANTATION: BRAZILIAN SUMMARY SLIDES – 2025
The development of the Brazilian Registry of Hematopoietic Cell Transplantation (HCT) in collaboration with the Center for International Blood and Marrow Transplant Research (CIBMTR) continues to provide a comprehensive assessment of the activity and general outcomes of HCT in Brazil. In this paper, we report an update of such activity. Brazilian transplant centers report their data to the CIBMTR, using the FormsNet3 platform. The data then return to the Brazilian Cellular Therapy and Bone Marrow Transplant Society (SBTMO) through the Data Back to Centers (DBtC) tool. Data from patients who received an HCT from 2012 to 2024 from Brazilian centers were extracted from the CIBMTR. A descriptive analysis was carried out using patient, disease and transplant-specific variables and overall survival analysis using the Kaplan Meier method. A total of 14,331 patients were eligible for this study (6,583 autologous and 7,748 allogeneic HCTs). The number of reporting centers increased from 40 to 45 during the period. The most common HCT indication in Brazil for allogeneic HCT was AML, with 171 HCTs per year and, for autologous HCT, multiple myeloma, with 273 HCTs per year. Among allogeneic HCT, in the last 4 years, mismatched related donor was the main source of donors. Regarding the graft source for allogeneic HCTs, bone marrow (BM) was the most frequent among pediatric HCTs, while peripheral blood (PB) was the most used in adults. Infections were the leading cause of death in the first 100 days after all types of HCTs. Patients with acute leukemia who underwent HCT at an advanced disease stage had lower survival rates compared to those at earlier stages. Despite the differences in the number of cases and follow-up time, the results in this study were similar to those presented in the United States (USA) Summary Slides.
Authors
- Roberto Luiz da Silva (ORCID: https://orcid.org/0000-0001-5445-7194)
- João Victor Piccolo Feliciano (ORCID: https://orcid.org/0000-0002-2034-7015)
- Paula Moreira da Silva Sabaini (ORCID: https://orcid.org/0000-0002-1359-7833)
- Monique Ammi
- Vanderson Rocha (ORCID: https://orcid.org/0000-0003-0094-619X)
- Vaneuza Araújo Moreira Funke (ORCID: https://orcid.org/0000-0002-2122-7277)
- Flavia Ferreira da Costa (ORCID: https://orcid.org/0000-0003-2735-352X)
- Volney Assis Lara Vilela (ORCID: https://orcid.org/0000-0002-2062-7834)
- Gianne Donato Costa Veloso (ORCID: https://orcid.org/0009-0007-6349-1838)
- George Maurício Navarro Barros (ORCID: https://orcid.org/0000-0002-2816-3077)
- Carmem Bonfim (ORCID: https://orcid.org/0000-0003-0343-2610)
- Alexandre Silvério (ORCID: https://orcid.org/0000-0002-8593-2493)
- Fernando Barroso Duarte (ORCID: https://orcid.org/0000-0001-5170-695X)
- Mary E.D. Flowers (ORCID: https://orcid.org/0000-0003-1631-0911)
- Jayr Schmidt Filho (ORCID: https://orcid.org/0000-0001-8212-1620)
- Ricardo Chiattone (ORCID: https://orcid.org/0000-0001-7341-8502)
- Rodolfo Daniel de Almeida Soares (ORCID: https://orcid.org/0000-0001-5531-964X)
- Rony Schaffel (ORCID: https://orcid.org/0000-0002-0886-4474)
- Milton Aranha (ORCID: https://orcid.org/0009-0003-5625-005X)
- Phillip Scheinberg (ORCID: https://orcid.org/0000-0002-9047-4538)
- Gustavo Machado Teixeira (ORCID: https://orcid.org/0000-0002-4961-1596)
- Celso Arrais‐Rodrigues (ORCID: https://orcid.org/0000-0002-6395-6849)
- Anderson João Simione (ORCID: https://orcid.org/0000-0002-6939-906X)
- Juliana Folloni Fernandes (ORCID: https://orcid.org/0000-0002-5764-1621)
- Simone Ojima Ferreira (ORCID: https://orcid.org/0009-0001-3600-7007)
- Marcelo Alves Aduan
- Rosana Rocha Concilio (ORCID: https://orcid.org/0000-0001-6808-5598)
- Antônio Vaz de Macedo (ORCID: https://orcid.org/0000-0002-7633-8839)
- Rafael Dezen Gaiolla (ORCID: https://orcid.org/0000-0002-9480-4995)
- Samir Kanaan Nabhan (ORCID: https://orcid.org/0000-0001-8617-384X)
- Abrahão Elias Hallack Neto (ORCID: https://orcid.org/0000-0001-6671-9710)
- Ângelo Atalla (ORCID: https://orcid.org/0000-0002-5693-2443)
- Gustavo Bettarello (ORCID: https://orcid.org/0009-0004-2104-961X)
- Marcelo Capra (ORCID: https://orcid.org/0000-0002-5224-1979)
- Adriana Seber (ORCID: https://orcid.org/0000-0003-4578-9423)
- Rodolfo Calixto (ORCID: https://orcid.org/0000-0001-7893-5082)
- Simone De Castro Resende Franco (ORCID: https://orcid.org/0009-0001-3444-2945)
- Nelson Hamerschlak (ORCID: https://orcid.org/0000-0002-5140-5310)
- João Samuel de Holanda Farias (ORCID: https://orcid.org/0000-0002-8625-919X)
- Afonso Celso Vigorito (ORCID: https://orcid.org/0000-0002-9990-1313)
- Adriana Mendes de Quadros Cavilha (ORCID: https://orcid.org/0000-0001-9669-5297)
- Vinícius Campos de Molla (ORCID: https://orcid.org/0000-0002-3598-2572)
- Cláudia Cáceres Astigarraga
- Joaquim Gasparini dos Santos (ORCID: https://orcid.org/0000-0001-6096-116X)
- Décio Lerner (ORCID: https://orcid.org/0000-0003-1104-591X)
- Leonardo Javier Arcuri (ORCID: https://orcid.org/0000-0002-9673-1945)
- Maria Cristina Martins de Almeida Macedo (ORCID: https://orcid.org/0000-0002-6105-9968)
- Liane Esteves Daudt (ORCID: https://orcid.org/0000-0001-9495-6932)
- Vergílio Antônio Rensi Colturato (ORCID: https://orcid.org/0000-0001-7842-2957)
- Cinthya Corrêa da Silva (ORCID: https://orcid.org/0000-0002-8923-5062)
- Yana Novis (ORCID: https://orcid.org/0000-0001-6590-069X)
- Heliz Regina A. Neves (ORCID: https://orcid.org/0000-0002-6717-0464)
- Ricardo Pasqüini (ORCID: https://orcid.org/0000-0002-9272-1061)
- Marcelo C. Pasquini (ORCID: https://orcid.org/0000-0003-1579-2293)
- Maria Cláudia Rodrigues Moreira
- Marcos Paulo Colella (ORCID: https://orcid.org/0000-0002-4292-6472)
- Andresa Lima Melo (ORCID: https://orcid.org/0000-0003-4922-7073)
Institutions
- Gaertner (United States) (US)
- Faculdade de Medicina de São José do Rio Preto (BR)
- Universidade Federal Fluminense (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Medical College of Wisconsin (US)
- Hospital Israelita Albert Einstein (BR)
- AC Camargo Hospital (BR)
- Hospital Moinhos de Vento (BR)
- Real Hospital Português (BR)
- Hospital Universitário - Universidade Federal de Juiz de Fora (BR)
- Fred Hutch Cancer Center (US)
- Hospital de Câncer de Barretos (BR)
- Support group for adolescents and children with cancer (BR)
- Instituto de Cardiologia do Distrito Federal (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Samaritano de São Paulo (BR)
- São Camilo Hospital (BR)
- Centro Paulista de Investigação Clinica (BR)
- Hospital Universitário Walter Cantídio (BR)
- Hospital Erasto Gaertner (BR)
- Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória (BR)
- Hospital Nossa Senhora das Graças (BR)
- Hospital IPO (BR)
- Hospital Amaral Carvalho (BR)
- Beneficência Portuguesa de São Paulo (BR)
- Versiti Blood Center of Wisconsin (US)
- Hospital Central da Polícia Militar (BR)
- Hospital das Clínicas da Universidade Federal de Minas Gerais (BR)
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Hospital Universitário de Brasília (BR)
- Hospital Universitário Clementino Fraga Filho (BR)
- Instituto Nacional de Câncer - INCA (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
- National Institute Of Blood Disease and Bone Marrow Transplantation (PK)
- Centro Universitário Academia (BR)
- Centro de Pesquisas Oncológicas (BR)
- Instituto Brasileiro de Controle do Câncer (BR)
- Hospital Mãe de Deus (BR)
- Universidade Estadual de Montes Claros (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY
- Published
- 2025-05-31
- DOI
- https://doi.org/10.46765/2675-374x.2025v6n1p259
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88