Benefit from adjuvant radiotherapy in early-stage oral cavity and oropharyngeal cancer with solitary ipsilateral lymph node metastasis – A population-based study on German cancer registry data
This clinical cancer registry study portends an oncological benefit of adjuvant RT for patients with early-stage (pT1/pT2) OSCC and p16-negative OPSCC who present with solitary ipsilateral lymph node metastasis. This benefit was particularly notable in the sub-cohort of younger patients with p16-negative OPSCC and the sub-cohort of elderly patients with OSCC.
Authors
- Daniel Zips (ORCID: https://orcid.org/0000-0001-5779-9675)
- Ian Wittenberg
- Andrea Sackmann
- Christian Doll (ORCID: https://orcid.org/0000-0002-0439-759X)
- Steffen Dommerich (ORCID: https://orcid.org/0000-0001-7769-0634)
- Anne Letsch
- Anna Trelinska-Finger
- Fabian Reinwald
- Barbara Franke (ORCID: https://orcid.org/0000-0003-4375-6572)
- Marcus Beck (ORCID: https://orcid.org/0000-0003-1940-2571)
- Ingeborg Tinhofer (ORCID: https://orcid.org/0000-0002-0512-549X)
- Sylke Ruth Zeißig (ORCID: https://orcid.org/0000-0002-0743-6128)
- Elena Hofmann (ORCID: https://orcid.org/0000-0003-4458-9278)
- Maren Knödler (ORCID: https://orcid.org/0000-0001-7475-6829)
- Konrad Klinghammer (ORCID: https://orcid.org/0000-0001-6425-4833)
- Monika Klinkhammer‐Schalke (ORCID: https://orcid.org/0000-0001-5066-2051)
- Max Heiland (ORCID: https://orcid.org/0000-0002-4987-2913)
- Kerstin Weitmann (ORCID: https://orcid.org/0000-0003-0386-283X)
- Constanze Schneider
Institutions
- Hess (United States) (US)
- University of Würzburg (DE)
- Universitätsmedizin Greifswald (DE)
- Humboldt-Universität zu Berlin (DE)
- German Cancer Society (DE)
- Experimental Factory Magdeburg (DE)
- NHS Digital (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Oral Oncology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.oraloncology.2025.107384
- Citations
- 7
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.94