Solitary fibrous tumor in the lower limb: A rare case report emphasizing the importance of long-term surveillance
Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm of fibroblastic differentiation, characterized by unpredictable biological behavior. Although initially described in the pleura, it may occur in extrapleural sites, including soft tissues of the limbs, although this is uncommon. The definitive diagnosis relies on histopathological analysis combined with immunohistochemical markers such as CD34 and STAT6, the latter being highly sensitive and specific for SFT. While SFT often exhibits an indolent course, approximately 10% to 30% of cases may develop local recurrences or metastases, reinforcing the importance of prognostic risk stratification and long-term follow-up after surgical resection. • Case report of a rare solitary fibrous tumor (SFT) in the lower limb. • Diagnosis was difficult and required immunohistochemistry (CD34 and STAT6) . • Tumor came back 17 months after surgery , showing the need for long-term follow-up. • Limited access to tests in low-income areas can delay diagnosis and treatment. • The study highlights the need for better hospital resources and trained professionals .
Authors
- Jessica Vanina Ortiz (ORCID: https://orcid.org/0000-0001-7214-6816)
- Luis Enrique Bermejo Galan (ORCID: https://orcid.org/0000-0002-7467-3692)
- Ana Cássia Silva Oliveira
- Felipe A. Cerni
- Manuela B. Pucca (ORCID: https://orcid.org/0000-0003-2594-7068)
- Glyciane Vieira da Silva (ORCID: https://orcid.org/0009-0007-9334-824X)
- Roberto Carlos Cruz Carbonell (ORCID: https://orcid.org/0000-0003-2410-3154)
- Pablo André Brito de Souza
- Geovanna M. Malachias-Pires (ORCID: https://orcid.org/0009-0006-8825-3708)
- Bruna Kempfer Bossoli
Institutions
- Universidade Federal de Roraima (BR)
- Centro Universitário de Araraquara (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Medical Reports
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.hmedic.2025.100270
- Primary Topic
- Soft tissue tumor case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo