Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer
The synergistic delivery of the targeted tumor cell-intrinsic CTRP6 biomimetic nanocarrier provides a new approach to the combined immunotherapy of lung cancer.
Authors
- Zhilin Sui
- Songhua Cai (ORCID: https://orcid.org/0000-0003-3839-2030)
- Lixu Wang (ORCID: https://orcid.org/0000-0003-2518-4160)
- Baihua Zhang (ORCID: https://orcid.org/0000-0002-0071-8480)
- Zhentao Yu (ORCID: https://orcid.org/0000-0001-9684-6390)
- Jing Huang (ORCID: https://orcid.org/0000-0001-7593-0980)
- Jie He (ORCID: https://orcid.org/0000-0002-4324-1125)
- Chujian Huang
- Xiaotong Guo (ORCID: https://orcid.org/0000-0002-4039-613X)
- Ran Jia (ORCID: https://orcid.org/0000-0001-9895-5734)
- Youjun Deng (ORCID: https://orcid.org/0000-0002-2904-6438)
- Hongjie Fan (ORCID: https://orcid.org/0000-0002-0211-2888)
- Kai Ma (ORCID: https://orcid.org/0000-0001-7535-1313)
Institutions
- Union Hospital (HK)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12951-025-03428-5
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen
- Shenzhen Science and Technology Innovation Program