Comparison of Optical Coherence Tomography Features of Vogt–Koyanagi–Harada Disease and Central Serous Chorioretinopathy

Purpose: The purpose of the study was to compare and analyze the optical coherence tomography (OCT) features of Vogt–Koyanagi–Harada disease (VKH) and central serous chorioretinopathy (CSCR). Materials and Methods: A retrospective review of OCT records was done for eyes with VKH and CSCR. We enrolled 50 eyes that presented to us with CSCR and 35 eyes with VKH. Various OCT features were analyzed using a two-tailed Z test between the two diseases. P <0.05 was considered to be statistically significant. Results: The mean age of patients with VKH was 37.0 ± 8.2 (21–49) years, and patients with CSR were 39.5 ± 6.7 (29–60) years. There was a male predominance in the CSR group, which was not found in the VKH group (91.3% in CSR vs. 36.8% in VKH). Subretinal fluid was noted in all the cases of VKH (100%) and CSCR (100%). Patients with VKH had a higher probability of exhibiting features such as hyperreflective dots in the vitreous, internal limiting membrane fluctuation, intraretinal fluid accumulation, bacillary layer detachment, subretinal hyperreflective dots, subretinal septae, retinal pigment epithelium (RPE) folds, and granular surface of RPE ( P < 0.05). Pigment epithelium detachment was noted in a higher probability in cases of CSCR than VKH ( P < 0.05). The mean foveal thickness noted in eyes with CSCR was lower at 405.56 ± 18.33 µm (microns) than in VKH at 552.14 ± 65.58 µm ( P = 0.03). Conclusion: CSCR and VKH share certain OCT characteristic features; however, they may be more commonly seen in one condition as opposed to the other.