Late-onset Krabbe disease: Spectrum of radiological findings

Krabbe disease (KD) is a lysosomal disease caused by an enzyme defect that causes galactocerebrosidase to accumulate in tissue. It causes radiological findings in the leukodystrophy pattern. This article aims to interpret the most common and rare radiological findings. Magnetic resonance imaging and computed tomography examinations revealed corticospinal tract, periventricular white matter, corpus callosum and dentate nucleus involvement, and cerebral calcification in four children with late-onset KD. The most common finding is pathological signal in the corticospinal system; the rarest finding is calcification.