Genome-wide interaction study with body mass index identifies <i>CYP7A1</i> and <i>GIPR</i> as genetic modulators of metabolic dysfunction-associated steatotic liver disease
A genome-wide single nucleotide polymorphism×BMI design fuelled identification of two MASLD genes: CYP7A1 and GIPR.
Authors
- S. U. Qadri (ORCID: https://orcid.org/0000-0001-9313-9324)
- Oveis Jamialahmadi (ORCID: https://orcid.org/0000-0001-7139-4738)
- Marcel den Hoed (ORCID: https://orcid.org/0000-0001-8081-428X)
- Stefano Romeo (ORCID: https://orcid.org/0000-0001-9168-4898)
- Umberto Vespasiani‐Gentilucci (ORCID: https://orcid.org/0000-0002-1138-1967)
- Frits R. Rosendaal (ORCID: https://orcid.org/0000-0003-2558-7496)
- Inês Cebola (ORCID: https://orcid.org/0000-0003-3528-4982)
- Amin Allalou
- Anastasia Emmanouilidou (ORCID: https://orcid.org/0000-0003-1512-5634)
- Hannah Maude (ORCID: https://orcid.org/0000-0002-7593-4516)
- Luca Valenti (ORCID: https://orcid.org/0000-0001-8909-0345)
- Luisa Ronzoni (ORCID: https://orcid.org/0000-0001-7820-6533)
- Endrina Mújica (ORCID: https://orcid.org/0000-0003-1348-8765)
- Ester Ciociola (ORCID: https://orcid.org/0000-0003-1186-5563)
- Ruifang Li‐Gao (ORCID: https://orcid.org/0000-0003-0650-1351)
- Samantha Maurotti (ORCID: https://orcid.org/0000-0001-7644-1337)
- Francesco Malvestiti (ORCID: https://orcid.org/0000-0002-2430-5883)
- Rosellina Margherita Mancina (ORCID: https://orcid.org/0000-0002-1126-3071)
- Federica Tavaglione (ORCID: https://orcid.org/0000-0002-1720-4355)
- Lowri Morris
- H Yki-Järvinen
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- Uppsala University Hospital (SE)
- Università Campus Bio-Medico (IT)
- University of Milan (IT)
- Leiden University Medical Center (NL)
- Science for Life Laboratory (SE)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of California San Diego (US)
- Magna Graecia University (IT)
- Minerva Foundation (FI)
- Campus Bio Medico University Hospital (IT)
- Genomics England (GB)
- Link Campus University (IT)
- Imperial College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3350/cmh.2025.0159
- Citations
- 4
- Primary Topic
- Congenital Ear and Nasal Anomalies
- Type
- article
- Field-Weighted Citation Impact
- 6.50
Funders
- Imperial College London
- Cancerfonden
- Hjärt-Lungfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Novo Nordisk Fonden
- National Institutes of Health
- Uppsala Multidisciplinary Center for Advanced Computational Science
- National Institute of Diabetes and Digestive and Kidney Diseases