Development of a near-infrared fluorescence probe for hypochlorous acid based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism
Near-infrared (NIR) fluorescence probes for hypochlorous acid (HClO) are powerful tools for investigating various biological phenomena because of their low autofluorescence, high tissue penetration and usefulness for multicolour imaging. Here we present a rational probe design strategy based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism and apply it to develop a NIR fluorescence probe for HClO, N-Phenol SiR1. This probe was applied for multicolor (4 colors) live-cell fluorescence imaging, occupying the NIR color window.
Authors
- Takahiro Kuchimaru (ORCID: https://orcid.org/0000-0002-5355-3165)
- H. Ohno (ORCID: https://orcid.org/0009-0008-0177-782X)
- Sota Yamada (ORCID: https://orcid.org/0000-0002-5083-5650)
- Kenjiro Hanaoka (ORCID: https://orcid.org/0000-0003-0797-4038)
- Eita Sasaki (ORCID: https://orcid.org/0000-0002-8202-4465)
- Ariunbold Chuluun-Erdene
- Shun Sumitani
Institutions
- Jichi Medical University (JP)
- Keio University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02212f
- Citations
- 3
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.27
Funders
- Japan Agency for Medical Research and Development
- Keio University
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology