Gastrointestinal exposure to silica nanoparticles induced Alzheimer’s disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC
We showed for the first time that gastrointestinal exposure to SiO<sub>2</sub> NPs depends on the gut microbiome and causes neurological and cognitive impairment via gut-brain axis information transmission. These findings suggest that the gut microbiota, as a mediator between intestinal and brain information communications, contributes to gastrointestinal exposure to SiO<sub>2</sub> NPs-induced neurotoxicity. The health risks of exposure to SiO<sub>2</sub> NPs should be recognised, and addressing strategies should be extensively reconsidered.
Authors
- Longxing Wang
- Ziying Hong (ORCID: https://orcid.org/0000-0003-4160-9739)
- Benjie Wang (ORCID: https://orcid.org/0000-0001-7022-5588)
- Lisha Du (ORCID: https://orcid.org/0009-0006-7374-1565)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0001-6972-5606)
- Yadong Wang (ORCID: https://orcid.org/0000-0003-2067-382X)
- Xiaofei Han (ORCID: https://orcid.org/0000-0001-5021-6262)
- Renjun Wang (ORCID: https://orcid.org/0000-0003-3307-3276)
- Xinyi Wang (ORCID: https://orcid.org/0009-0003-5429-9853)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12951-025-03481-0
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31