Safinamide as an adjunct to levodopa monotherapy in Asian patients with Parkinson’s disease experiencing early wearing-off: a pooled analysis of the J-SILVER and KEEP studies
Safinamide as an adjunct to levodopa monotherapy was effective for early wearing-off without any new tolerability concerns. Safinamide was particularly beneficial in elderly patients.
Authors
- Nobutaka Hattori (ORCID: https://orcid.org/0000-0002-2034-2556)
- Jong Sam Baik (ORCID: https://orcid.org/0000-0002-5300-203X)
- Chizuru Kobayashi
- Do-Young Kwon (ORCID: https://orcid.org/0000-0002-9773-622X)
- Yuki Kogo (ORCID: https://orcid.org/0000-0002-8120-3971)
- Noriko Nishikawa (ORCID: https://orcid.org/0000-0001-7762-3597)
- Jin Whan Cho (ORCID: https://orcid.org/0000-0002-9145-6729)
- Taku Hatano (ORCID: https://orcid.org/0000-0002-6808-0444)
- Jieun Kim (ORCID: https://orcid.org/0000-0001-8656-6387)
- Takayuki Ishida
- Hiroyuki Shiiba
Institutions
- Samsung Medical Center (KR)
- Ansan University (KR)
- Juntendo University (JP)
- Inje University Sanggye Paik Hospital (KR)
- Eisai (South Korea) (KR)
- Eisai (Japan) (JP)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3389/fneur.2025.1591664
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Eisai