Clinical Characteristics and Correlations of Prostate Pathologies with PSA Levels: A Retrospective Study at a Tertiary Hospital

Introduction: Despite diagnostic advances, prostate cancer is a major health concern among aging men. Few studies have been conducted in Palestine for the assessment of prostate pathologies. Thus, the aim of the present study was to investigate the clinical characteristics and correlation of prostate pathologies with PSA levels. Methods: This retrospective study, conducted at An-Najah National University Hospital, enrolled patients who underwent prostate biopsy between 2020 and 2022. The data collected included demographics, PSA levels, and histopathological reports. Statistical analyses were performed to explore associations between variables. Results: In 111 participants, prostate adenocarcinoma was the most prevalent histopathology (41%). Majority of patients came from 61-80 year age group with mostly PSA levels ranging from 4.1 to 100 ng\ml . Gleason scores of 8 and 9 were highest in number. Weak correlations between age, PSA level and Gleason score were noted. Conclusion: This study provides insights into the clinical profile of prostate cancer patients within the Palestinian population. There is need for further research to improve diagnostic approaches and personalized management strategies to optimize patient care and outcomes.