Comparative Effectiveness of kanchnar guggulu and yoga Practice in the Management of Subclinical Hypothyroidism. Study Protocol for A Randomized Open Labelled Comparative Clinical

Abstract: Background :The common cause of hypothyroidism is the inability of thyroid gland to produce a sufficient amount of thyroid hormones. India has a high prevalence of hypothyroidism which is about 10%. In subclinical hypothyroidism, no treatment is advised. The aim of this study to evaluate the effectiveness of Yogapractice incomparison with kanchnarguggulu in the management of subclinical hypothyroidism. Methods And Design: This study will be a prospective, single-centered, a randomized open labelled comparative clinical trial. A total of 60 patients of age between 19 and 60 years, diagnosed with subclinical hypothyroidism, will be randomized into two groups. In group A, patients will be given kanchnarguggulu and in group B patients will be guidedYoga practice. Both groups will receive treatment for 60 days. Outcomes will be evaluated on the 30th days and 60th days. The primary outcome will be evaluated on the basis of improvement in the serum TSH level in significant range. Secondary outcomes will be evaluated on the basis of improvement in the lab values of Serum Cholesterol, Serum Triglyceride and Serum Creatinine & quality of life of patient will be improved. Conclusion:This trial is the first to compare the effectiveness ofkanchnarguggulu and Yoga practice in the management of subclinical hypothyroidism. Yoga practice is expected to improve the symptoms of subclinical hypothyroidism, thus proving to be effective in the management of patients with subclinical hypothyroidism. Trial Registration: CTRI/2025/02/080040