Clinical and Radiographical Evaluation of Platelet Rich Fibrin Mixed with Nanocrystalline Hydroxyapatite Bone Graft for Healing of Maxillary Bony Defects

Introduction: Platelet Rich Fibrin (PRF) combined with NanocrystallineHydroxyapatite bone graft offers a promising approach for enhancing boneregeneration in maxillary bony defects. Aim: To evaluate postoperative clinical andradiographic outcomes of maxillary intrabony defects using a mix of nanocrystallinehydroxyapatite (nHA) bone graft with platelet rich fibrin (PRF) after removal ofmaxillary cystic lesions. Materials and Methods: Sixteen patients necessitating thesurgical removal of intra-bony cystic lesions were enrolled in a randomized controlledinvestigation and subsequently allocated to one of two study arms. Eight patients,forming the control cohort (Group I), underwent conventional healing without the useof grafting materials following surgical excision of the cystic lesions. In contrast, thestudy cohort (Group II), also comprising eight patients, received a graft composedof nanocrystalline hydroxyapatite and platelet-rich fibrin following lesion removal.Results: Analysis of the collected data demonstrated a statistically significant lowerpain score in study group in the seventh day (p = 0.012). The study group showed amore rapid resolution of edema compared to the control group, although differencesbetween groups at individual time points did not reach statistical significance (p =1.000). Notably, the study group exhibited a highly statistically significant increasein bone density at the T1 time interval compared to the control group (P < 0.001). Incontrast, baseline bone density measurements (T0) showed no statistically significantdisparity between the two groups (P = 0.466). No Postoperative complications for bothgroups as infection, wound dehiscence, or looseness of adjacent teeth at 1-, 7-, and14-days post-operative.Conclusion: PRF combined with nanocrystalline hydroxyapatite may be considereda potential material for promoting bone repair following the enucleation of maxillarycystic lesions.