Effect of low-level laser therapy on cisplatin induced cytotoxicity in parotid gland of rats.

Objective: the current study was designed to evaluate the therapeutic efficacy of low-level laser therapy (LLLT) on parotid glands following cytotoxicity produced by cisplatin in rats. Subject and Methods: The study employed a sample of 36 adult males Sprague-Dawley rats were divided into three groups, each consisting of 12 rats. Group I: control group received phosphate-buffered saline. Group II: referred to as the cisplatin group, was administered a solitary intraperitoneal injection of the cisplatin medication at a dosage of 10mg/kg. Group III: received the dose of cisplatin used in group II, then exposed to a single session of LLLT on day 3 after cisplatin administration. After cisplatin injection and low-level laser irradiation, animals were sacrificed at 7 and 14 days. The sacrifice was examined histologically and ultra structurally. Results: The experimental LLL-treated group showed some improvement in the gland but could not regenerate to normal arctecture. Conclusion: This study proved that LLL cannot improve cytotoxicity induced by cisplatin in parotid glands.